Acetaminophen overdose is the #1 cause of liver failure in the US. According to a Reuters article, there are 1600 cases of liver failure per year 2007, 450 from acetaminophen overdose. This is a large number. In comparison consider that the cholesterol drug Cerivastatin Baycol was withdrawn from the market when there were 31 deaths from rhabdomyalysis severe muscle break-down, which is far more common than liver failure in these drugs. These happened mainly when the drug was used in combination with another cholesterol drug.